Watch Closely (1)lumefantrine will decrease the level or effect of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. For people receiving exemestane using a powerful CYP3A4 inducer the advisable dose of exemestane is 50 mg day by day after a meal.larotrectinib will raise the degree or impact of exemestane by af